Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• such as photothermal therapy, imaging, and LFAs [73]. Composition-dependent photothermal properties Recently, nanocomposite materials have been employed for the development of photothermal biosensors for the detection of cancer biomarkers or whole cancerous cells, antibiotic residues, and toxins [74

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• higher binding affinity and specificity, mAbs have received a lot of attention for the detection of selective cancer biomarkers and also for the treatment of various types of cancer. Antibody-conjugated nanoparticles (ACNPs) are an effective targeted therapy for the efficient delivery of

Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review

• Ioana Marica,
• Fran Nekvapil,
• Maria Ștefan,
• Cosmin Farcău and
• Alexandra Falamaș

Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40

• been detected [113]. ZnO platforms are inexpensive to produce, non-toxic and biodegradable, showing potential for improving the detection of various molecules as fluorophores, dyes, or cancer biomarkers. Thus, the use of ZnO NPs as substrates for fluorescence enhancement is an alternative to overcome

• protein reactions. The study demonstrated that ZnO substrates can be employed as efficient nanoplatforms for rapid identification and screening of interacting protein pairs. A significant fluorescence amplification was reported for ZnO NRs substrates for the detection of two important cancer biomarkers

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• nanoparticles; plasmonics; single-point mutation; Introduction Cancer is a leading cause of death accounting for about 8.8 million deaths in 2015 [1]. The list of tumor-linked substances, i.e., biomarkers for diagnosis and prognosis purposes is continuously increasing. Cancer biomarkers are present in tumor

Evaluation of click chemistry microarrays for immunosensing of alpha-fetoprotein (AFP)

• Seyed Mohammad Mahdi Dadfar,
• Sylwia Sekula-Neuner,
• Vanessa Trouillet,
• Hui-Yu Liu,
• Ravi Kumar,
• Annie K. Powell and
• Michael Hirtz

Beilstein J. Nanotechnol. 2019, 10, 2505–2515, doi:10.3762/bjnano.10.241

• (AOC), Karlsruhe Institute of Technology (KIT), Engesserstraße 15, 76131 Karlsruhe, Germany 10.3762/bjnano.10.241 Abstract The level of cancer biomarkers in cells, tissues or body fluids can be used for the prediction of the presence of cancer or can even indicate the stage of the disease. Alpha

• categories: imaging and biomarker tests. Cancer biomarkers are measurable molecules or substances observed in cells, tissues or body fluids, and their level predicts the presence of cancer or even indicates the stage of cancer. The measurement of biomarkers always leads to a specific numeric value, and the

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• -linked immunosorbent assay. The approaches for immunoassays and data processing are generic, and therefore the strategies described here may provide a simple platform for clinical diagnosis of cancers and other types of diseases. Keywords: cancer biomarkers; magnetite nanoparticles; microfluidic devices

• specificity, PSA screening has contributed to a significant decline (45–70%) in prostate cancer mortality since the early 1990s [1]. To identify cancer biomarkers and to develop methodologies to quantify them at low cost is critical for early cancer diagnostics, while it also helps to understand cancer

• sensing performance. Electrochemical immunosensors containing magnetic nanoparticles have been used to detect several cancer biomarkers [22][23][24]. Zhuo and co-workers detected carcinoembryonic antigen (CEA) and α-fetoprotein (AFP) with a three-layer immunosensor with Fe3O4 magnetic core modified with a

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

• nanoparticles can be used for molecular-selective recognition of cancer biomarkers. The overexpression of specific biomarkers with cancer development will lead to the increase in concentration of optically active nanoobjects in the tumor zone and, consequently, to the diagnostic contrast enhancement (Figure 9

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)

• Paula Ciaurriz,
• Fátima Fernández,
• Edurne Tellechea,
• Jose F. Moran and
• Aaron C. Asensio

Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27

• literature, as published by Ambrosia and co-workers in studying the effect of AuNP complexes in enhanced ELISA for the detection of breast cancer biomarkers [12]. In this work, the authors assessed three different concentrations of AuNP probes (ranging approximately from 1.4 to 0.014 AU) discarding the

A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a

• Maryam Daneshpour,
• Kobra Omidfar and
• Hossein Ghanbarian

Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193

• various cancers have presented them as the suitable cancer biomarkers [4]. There is also growing evidence that miRNAs exist not only in cells but also in a variety of body fluids, including blood [5], saliva [6], and urine [7]. Those miRNAs that can be found in bloodstream are called circulatory miRNAs

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• . prepared a nanocomposite consisting of reduced graphene oxide hybridized with electrochemically co-reduced gold nanoparticles and ferrocene as a sensitive immunosensor of breast cancer biomarkers [14]. Very recently, Mars et al. showed that the aggregation of gold nanoparticles through a ferrocene-based